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In vivo study on apoptosis and cell proliferation induced by adriamycin in mice with MCF-7 breast cancer

Wenwu Wang

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Abstract

AIM: To observe the apoptosis and cell proliferation induced by adriamycin in mice with breast cancer. METHODS: Therapeutic effect of 1.25 mg·kg -1 adriamycin (ADR) on mice MCF-7 breast cancer was observed in vivo. Apoptosis and PCNA of tumor cells were also studied by TUNEL and immunohistochemical methods. RESULTS: In the control group, the apoptotic cell index (AI) in tumor cell was 1.11% and PCNA index (PI) was 56.38%. In the ADR group, the rate of tumor inhibition was 43% and the AI was 1.93% (P 0.05). The 35.75% of PI in ADR group was lower than that in the control group (P 0.01). CONCLUSION: Adriamycin may induce apoptosis and reduce cell proliferation.

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AIM: To observe the apoptosis and cell proliferation induced by adriamycin in mice with breast cancer. METHODS: Therapeutic effect of 1.25 mg·kg -1 adriamycin (ADR) on mice MCF-7 breast cancer was observed in vivo. Apoptosis and PCNA of tumor cells were also studied by TUNEL and immunohistochemical methods. RESULTS: In the control group, the apoptotic cell index (AI) in tumor cell was 1.11% and PCNA index (PI) was 56.38%. In the ADR group, the rate of tumor inhibition was 43% and the AI was 1.93% (P 0.05). The 35.75% of PI in ADR group was lower than that in the control group (P 0.01). CONCLUSION: Adriamycin may induce apoptosis and reduce cell proliferation.

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Available abstract

AIM: To observe the apoptosis and cell proliferation induced by adriamycin in mice with breast cancer. METHODS: Therapeutic effect of 1.25 mg·kg -1 adriamycin (ADR) on mice MCF-7 breast cancer was observed in vivo. Apoptosis and PCNA of tumor cells were also studied by TUNEL and immunohistochemical methods. RESULTS: In the control group, the apoptotic cell index (AI) in tumor cell was 1.11% and PCNA index (PI) was 56.38%. In the ADR group, the rate of tumor inhibition was 43% and the AI was 1.93% (P 0.05). The 35.75% of PI in ADR group was lower than that in the control group (P 0.01). CONCLUSION: Adriamycin may induce apoptosis and reduce cell proliferation.

Key concepts: Apoptosis, Proliferating cell nuclear antigen, MCF-7, In vivo, TUNEL assay, Cell growth, Proliferation index, Breast cancer

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In vivo study on apoptosis and cell proliferation induced by adriamycin in mice with MCF-7 breast cancer — Research Paper | ScholarLens