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Expression and Significance of ER,PR,Her-2 and p53 in Ovarian Epithelial Carcinoma

Liu Jianmin

Abstract

Objective To explore the expression and significance of ER,PR,Her-2 and p53 in ovarian epithelial carcinoma.Methods The expression of ER,PR,Her-2,p53 in ovarian epithelial carcinoma were detected by immunohistochemistry method,and analyzing ER,PR,Her-2,P53's relation with pathological mechanism microanatomy type,microanatomy classifies and clinical periodization.Results The positive expressions of ER,PR,Her-2,p53 in 43 patients with epithelial ovarian cancer were 55.8%,60.5%,23.3% and 67.4%;The expressions of ER has no relation with pathological mechanism microanatomy type,microanatomy classifies and clinical periodization.The expressions of PR,Her-2,p53 had relation with clinical periodization.The expression level of PR in stageⅠ～Ⅱ was higher than of stage Ⅲ～Ⅳ(P0.05);The expression level of Her-2 and p53 in stage Ⅲ～Ⅳ was higher than of stageⅠ～Ⅱ(P0.05).Conclusion The expression of ER,PR,Her-2 and p53 can help estimate ovary cancer prognosis and make rational therapeutic schedule for patients.

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Key concepts: Medicine, Immunohistochemistry, Periodization, Stage (stratigraphy), Pathological, Ovarian cancer, Ovary, Clinical significance