Effect of famotidine on pharmacokinetics of domperidone in healthy volunteers after a single oral administration

AIM: To study the effect of famotidine on the pharmacokinetics of domperidone. METHODS: A single oral dose of domperidone 10 mg was given to 10 healthy volunteers under the condition of untaking or taking famotidine in a randomized, cross-over study. Plasma domperidone concentration was determined by a validated LC/MS/MS method. Pharmacokinetic parameters were calculated by DAS software and compared by t tests. RESULTS: The concentration-time curve of domperidone with untaking or taking famotidine was conformed to a two-compartment model. Under untaking and taking famotidine conditions, the main pharmacokinetic parameters, t_ max , C_ max and AUC_ 0-tn , were 0.63 ± 0.36 and 1.50 ± 0.97 h , 9.91 ± 5.45 and 4.30 ± 5.01 μg·L -1 , 39.57 ± 10.46 and 32.43 ± 9.61 μg·h·L -1 respectively. The absorption of domperidone was delayed, and the peak concentration and area under curve were reduced significantly when famotidine was taken. CONCLUSION: Famotidine had a significant effect on the pharmacokinetics of domperidone after a single oral dose in healthy volunteer.