Relaionship between the expression of Survivin,Cox-2 and the clinical pathological factors in gastric carcinoma

Objective:To investigate the expression,relationship and clinical significance of Survivin and Cox-2 in gastric carcinoma.Methods:The exprssion of Survivin and Cox-2 were studied by immunohistochemistry SP in 60 gastric carcinoma specimen and 20 normal slice-edge mucosa gastric specimen.The relationship between exprssion of Survivin,Cox-2 and clinical pathological parameter were analyzed,also the relationship between Survivin and Cox-2.Results:The positive expression rates of Survivin were 68.3% and 0% in gastric carcinoma specimen and normal tissue respectively,while Cox-2 were 80.0% and 1.7%.The statistical results showed that expressions of Survivin and Cox-2 in gastric carcinoma were higher than those in normal gastric tissues(P0.01).The positive expression rate of Survivin was not related to gender,age,carcinoma size(P0.05).but was closely associated with cellular differentiation,serosa infiltration,lymph node metastasis(P0.05).The positive expression rate of Cox-2 was negatively related to gender,age,carcinoma size,cellular differentiation,serosa infiltration(P0.05),but was associated with lymph node(P0.05).The expression of Cox-2 was positively correlated to Survivin.Conclusion:Survivin and Cox-2 play important roles in the development and progress in gastric carcinoma.The expression of survivin and Cox-2 is positively correlated.They may have the same activating mechanism,and make up of many ways of carcinoma cellular apoptosis.The detection of Survivin and Cox-2 may act as one of efficient factors to indicate biological behavior and prognosis in gastric carcinoma.