Analysis on Distribution and Drug Sensitivity of Nosocomial Fungal Infections

Objective To investigate the distribution and drug susceptibility of nosocomial fungal infections,and to provide the reference for prevention of fungal infections and reasonable use of antifungal drugs. Methods Fungi were cultured and isolated by routine procedure,and then identified by API 20C AUX system.ATB FUNGUS 3 strips were used for MIC sensitivity test. Results The main sources of fungal infections in Hunan Provincial Tumor Hospital from June 2008 to June 2011 were department of thoracic medicine(35.2%),intensive care unit(29.0%),and department of internal medicine for the elderly officials(17.4%).The specimens with fungal infections were mainly collected from sputum(69 6%),followed by urine(9.2%),stool(7.4%) and secretion(6.8%).Among 500 strains of fungi,Saccharomyces albicans accounted for 54.6%,followed by Candida tropicalis(25.8%),pen-smooth Candida mycoderma bacteria(9.2%),and monilia krusei bacteria(8.2%).Among 500 strains of fungi,23.08% of Candida albicans(63/273) and 30.0% of non-albicans candida species(68/227) were insensitive to 5-flucytosine,30.8% of non-albicans candida species(70/227) were insensitive to fluconazole,and 87.8% of monilia krusei bacteria(36/41) were resistant to fluconazole.17.2% of non-albicans candida species(39/227) were insensitive to itraconazole,8.4% of non-albicans candida species(19/227) were insensitive to voriconazole.And 8.8% of non-albicans candida species(20/227) were insensitive to amphotericin B.All strains of Candida albicans were sensitive to fluconazole,itraconazole,voriconazole,and amphotericin B. Conclusions Most of clinical fungal infections were still caused by Candida albicans,but infections due to non-albicans candida species showed an increasing trend.The results of drug sensitivity tests showed that non-albicans candida species had relatively strong endurance to 5-flucytosine,fluconazole,and itraconazole.Therefore,conducting the antifungal drug susceptibility testing regularly and monitoring drug resistance can provide the reference for fungal infections prevention and rational use of antifungal medicines.