2010•Chinese Journal of New Drugs and Clinical RemediesRequires access

Determination of residual organic solvents in SM934 by gas chromatography

Cidan Shen

Abstract

AIM To establish a capillary gas chromatography method for the determination of residual organic solvents in SM934.METHODS A capillary gas chromatography with DM-5 capillary column(30 m × 0.25 mm,0.25 μm) was used to determine the residues of methanol,ethanol,dichloromethane,ethyl acetate,petroleum ether and N,N-dimethylformamide.RESULTS The six organic solvents were separated completely.The linear range was 13.0-250.0 mg.L-1.The average recovery rate was in the range of 97%-105%(RSD 4%).CONCLUSION This method is accurate,sensitive and reliable for the determination of residual organic solvents in quality control of SM934.

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Key concepts: Dichloromethane, Chemistry, Chromatography, Gas chromatography, Ethyl acetate, Methanol, Capillary gas chromatography, Petroleum ether