Determination of nine residual organic solvents in Domperidone by capillary gas chromatography

Objective A headspace capillary gas chromatography method was proposed for determination of residual organic solvents methanol,ethanol,dichloromethane,tetrahydrofuran,methyl isobutyl ketone,N,N-dimethylformamide,toluene,xylene in Domperidone and a capillary gas chromatography method was proposed for determination of residual organic solvents chloroform in Domperidone.Methods Determination of eight organic solvents:DB-1 capillary column was used with temperature of programmed control,FID detector was adopted in the determination;Determination of chloroform:DB-624 capillary column was used with temperature of programmed control,ECD detector was adopted in the determination.Results The content of nine solvents showed good linearityin a detected concentration rang(r0.999 0),the average were ranged from 91.09%~104.4%.Conclusion The method was accurate and rapid,and can be used for the quality control of residual organic solvents methanol in Domperidone.