Change on CD3~+,CD4~+ and CD8~+ T lymphocyte levels in peripheral blood of patients with gastric cancer

Objective To investigate the clinical significance and expression of peripheral blood T lymphocyte subset CD3+,CD4+,CD8+ and CD4+/CD8+ ratio in patients with gastric cancer.Methods Peripheral blood T lymphocyte subset CD3+,CD4+,CD8+ and CD4+/CD8+ ratio were determined by automatic blood cell analyzer in 40 patients with gastric cancer [according to the clinical stages:Ⅰ-Ⅱ stage group(18 cases) and Ⅲ-Ⅳ stage group(22 cases)] and 25 healthy subjects.Results The peripheral blood T lymphocyte subset CD3+,CD4+ and CD4+/CD8+ ratio in the gastric cancer group were 0.78%±0.35%,0.37%±0.21% and 0.61%±0.42%,respectively,which were significantly lower than those in the healthy control group(P0.05).The T lymphocyte subset CD3+,CD4+ and CD4+/CD8+ ratio in Ⅲ-Ⅳ stage group were 0.42%±0.27%,0.21%±0.17% and 0.29%±0.25%,which were significantly lower than those in Ⅰ-Ⅱ stage group(0.95%±0.35%,0.45%±0.19% and 0.76%±0.30%,P0.05).Conclusions The determinations of T lymphocyte subset CD3+,CD4+,CD8+ and CD4+/CD8+ ratio in peripheral blood of patients with gastric cancer are helpful to study and assess the immune status of patients,but also provide a theoretical reference to improve tumor immune therapy.