Association of the 301T>C of acylation stimulating protein gene polymorphism with coronary heart disease in Uygur patients in Xinjiang

Objective To investigate the association of the 301TC polymorphism of acylation stimulating protein(ASP) gene with coronary heart disease(CHD) and the influence of serum lipid levels in Uygur patients in Xinjiang.Methods The polymorphisms of gene in 385 patients with CHD(CHD group) and 483 patients with negative coronary angiography results(control group) were analyzed with PCR restriction fragment length polymorphism,and the serum lipid level was detected as well.Results The frequencies of TT,CT and CC genotype were 44.7%,43.1% and 12.2 % in CHD group,and were 53.8%,40.2% and 6.0% in control group,which showed significant differences between two groups(P0.01).Logistic regression analysis revealed that the risk of CHD was 0.784 times higher in individuals carrying CC genotype than that in individuals carrying TT genotype(OR=2.189,95%CI: 1.251 to 3.830).There was a significant difference in the level of serum triacylglycerol in different genotypes in CHD group(P0.05),and serum triacylglycerol level was higher in patients carrying CC genotype than that in patients carrying TT genotype(P0.05).Conclusion The 301TC polymorphism of ASP gene is correlated with the development of CHD,and C allele might be one of the risk factors of CHD.