A STUDY ON EFFICACY OF NALOXONE COMBINED rt-PA THERAPY FOR ACUTE CEREBRAL INFARCTION

Objective To observe the therapeutic efficacy and safety of naloxone combined rt-PA therapy for acute cerebral infarction(ACI).Methods Fifty patients consistent with the inclusion criteria were randomly divided into treatment group and control group.In addition to the routine treatment for both groups,the patients in treatment group were treated with naloxone and rt-PA,and patients in control group with rt-PA.Europe Stroke Scale(ESS) and Barthel Index(BI) were used to evaluate the recovery of neurological function in both groups before and after the treatment.Results ESS integral of 14 days and 21 days after treatment in treatment group was significantly higher than that of patients in control group.The total effective rate(88%) of three months after treatment in treatment group was significantly higher than that(60%) of patients in control group(t=3.389,4.914;χ2=5.889;P0.05).No significant differences in hemostasis and coagulation,side effects,complications were found between the two groups(t=0.316-1.351,P0.05).Conclusion The naloxone-rt-PA combination applied within six hours of acute cerebral infarction is safe and effective,which dramatically improves the patients' prognosis.