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2003•Unpublished venueRequires access

The therapeutic effect of naloxone on treating acute cerebral infarction of large area

Han Shuanre

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Abstract

Objective To investigate the clinical effect and safety of naloxone in treating patients with acute cerebral infarction of large area. Methods 91 patients with acute cerebral infarction of large area were randomly divided into two groups, treatment group (n=61) and control group (n=30). All the patients were treated with 20% mannitol in early stage, while the patients in treatment group were given naloxone in addition,2.4 mg once, twice a day, for 14 days. Results The recovery degree of nervous function in treatment group was much better than that of control group (P0.001). The effective rate and total effective rate in treatment group was 36.07% and 86.89 % respectively, compared with those of control group, there was a significant difference between two groups (P0.001). Conclusion Naloxone is an effective and safe drug for treating patients with acute cerebral infarction of large area.

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Objective To investigate the clinical effect and safety of naloxone in treating patients with acute cerebral infarction of large area. Methods 91 patients with acute cerebral infarction of large area were randomly divided into two groups, treatment group (n=61) and control group (n=30). All the patients were treated with 20% mannitol in early stage, while the patients in treatment group were given naloxone in addition,2.4 mg once, twice a day, for 14 days. Results The recovery degree of nervous function in treatment group was much better than that of control group (P0.001). The effective rate and total effective rate in treatment group was 36.07% and 86.89 % respectively, compared with those of control group, there was a significant difference between two groups (P0.001). Conclusion Naloxone is an effective and safe drug for treating patients with acute cerebral infarction of large area.

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Available abstract

Objective To investigate the clinical effect and safety of naloxone in treating patients with acute cerebral infarction of large area. Methods 91 patients with acute cerebral infarction of large area were randomly divided into two groups, treatment group (n=61) and control group (n=30). All the patients were treated with 20% mannitol in early stage, while the patients in treatment group were given naloxone in addition,2.4 mg once, twice a day, for 14 days. Results The recovery degree of nervous function in treatment group was much better than that of control group (P0.001). The effective rate and total effective rate in treatment group was 36.07% and 86.89 % respectively, compared with those of control group, there was a significant difference between two groups (P0.001). Conclusion Naloxone is an effective and safe drug for treating patients with acute cerebral infarction of large area.

Key concepts: Medicine, (+)-Naloxone, Anesthesia, Cerebral infarction, Therapeutic effect, Infarction, Clinical efficacy, Internal medicine

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