Study on the pulmonary surfactant Curosurf in preventing respiratory distress syndrome of prematures

Objective To evaluate the clinical effect of pulmonary surfactant Curosurf in preventing respiratory distress syndrome of prematures.Methods Thirty-six preterm infants with gestational age of 28-32 weeks and birth weight of 1 180-1 500 g were randomly divided into two groups.Among them,18 neonates of treated group were dripped in Curosurf through trachea within two hour after birth and 18 neonates served as control.Results The incidences of NRDS,complications and mortality in treated group were obviously lower than those in control group(P0.05).The results of blood gas analysis within six hours after birth showed that the treated group were much better than the control group(P0.01).Conclusion The preventive application of Curosurf early for prematures can remarkably reduce the rate of NRDS and mechanical ventilation dependence,and increase the survival rate.