2004•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access

Application of epidermal growth factor receptor tyrosine kinase inhibitors in cancer therapy

Yuan Shou

Abstract

Epidermal growth factor receptor (EGFR) tyrosine kinase is over-expressed in numerous human tumors, which plays pivotal roles in cellular signal transduction, and it is involved in a variety of tumor cellular behaviors such as proliferation, metastasis, angiogenesis and so on. Many investigations have indicated that tumor growth can be suppressed by inhibiting EGFR tyrosine kinase activity. Currently, several EGFR tyrosine kinase inhibitors are in clinical trial stage.

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Available abstract

Key concepts: Cancer research, Tyrosine kinase, Receptor tyrosine kinase, Platelet-derived growth factor receptor, Epidermal growth factor receptor, ROR1, Angiogenesis, Tropomyosin receptor kinase C