2003•Zhongguo aizheng zazhiRequires access

Progress of epidermal growth factor receptor and tyrosine kinase inhibitors in the cancer therapy

Zhang Min

Abstract

The signal transduction system induced by epidermal growth factor receptor(EGFR) regulates cell cycle ,modulates cell growth and differentiation and improves damage repair.The overexpression of EGFR in several epithelial tumors including non small cell lung cancer(NSCLC) forecasts low survival rate, poor prognosis and metastasis. Thereby EGFR can be a potential target for gene therapy. Tyrosine kinase inhibitors(TKIs) selectively inhibit tyrosine kinase activity,supress tumor growth ,and increase the sensitivity of radio chemotherapy. [

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Key concepts: Cancer research, Epidermal growth factor receptor, Tyrosine kinase, Receptor tyrosine kinase, Platelet-derived growth factor receptor, Growth factor receptor inhibitor, ROR1, Signal transduction