Influence Factors of Morning Blood Pressure Surge in Type 2 Diabetes Mellitus Patients with Essential Hypertension

Objective: To investigate the influence factors of morning blood pressure surge( MBPS)in type 2 diabetes mellitus( T2DM) patients with essential hypertension( EH). Methods: Levels of MBPS,blood lipids,blood glucose,fasting plasma C-peptide and Hb A1 c were recorded in 60 patients with T2 DM and EH. According to the levels of MBPS,patients were divided into group 1( MBPS ≤15 mm Hg),group 2( 15 mm Hg MBPS≤20 mm Hg) and group 3( MBPS 20 mm Hg). According to the antihypertensive scheme,patients were divided into group 1( no medication),group 2( using CCB),group 3( using ARB / ACEI). According to smoking status,patients were divided into group 1( no smoking) and group 2( smoking). The relationship between the MBPS and above parameters was analyzed. Results: Among the MBPS groups,there were significant differences in fasting plasma Cpeptide( P = 0. 035),while there was no significant difference in blood glucose,blood lipids and Hb A1c( P 0. 05). Among the antihypertensive medication groups,there were significant differences in MBPS( P 0. 05),as well as in smoking status groups. Multiple regression analysis showed that MBPS in no medication group,CCB group and ARB / ACEI group had the declining trend. MBPS was higher in smoking group than no smoking group. Conclusions: In patients with T2 DM and EH,MBPS was correlated with antihypertensive drugs and smoking status.