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The Study of the Expession of Fas and FasL Protein in Gastric Carcinoma Tissues Side-carcinoma Dysplasia Tissues and Normal Gastric Mucous Membrance

Xiaoping Jin

Abstract

Objective:To study the relationship between the expression of Fas and FasL protein and the pathogenosis and development of gastric carcinoma.Methods:The expression of Fas and FasL protein were detected by S-P immunohistochemistry technique.The apoptosis indexes(AI) examed by TUNEL methods.Results:The expression of Fas and FasL in gastric carcinoma tissues and side-carcinoma dysplasia tissues are remarkably higher than that in normal gastric mucous membrance(P0.01),The apoptosis indexes of normal gastric mucous membrance are remarkably lower than that of gastric carcinoma tissues(P0.05) and side-carcinoma dysplasia tissues(P0.01).Conclusion:The abnormal expression of Fas and FasL may be involved in the pathogenesis and the immune escape of gastric carcinoma.

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Key concepts: Fas ligand, Medicine, Gastric carcinoma, Immunohistochemistry, Apoptosis, TUNEL assay, Dysplasia, Pathogenesis