Relationship between Fas Antigen Expression and Apoptosis in Human Gastric Carcinoma Tissues

Objective To determine relationship between the expression of Fas antigen and apoptosis in human gastric carcinoma tissues.Method Using immunohistochemical staining and terminal deoxynucleotidyl transferase mediated dUTP nick end labeling(TUNEL) technique,we observed the apoptotic cells and Fas antigen expression in 40 cases of gastric carcinoma tissues.Results The positive rate of Fas antigen expression in gastric carcinoma tissues was 52.5%.The apoptotic index in Fas positive tissues was significantly higher than that in Fas negative tissues( t=3.35,P 0.01).Conclusions The result suggested that cellular apoptosis was closely related to the Fas antigen expression in gastric carcinoma tissues,the abnormal regulation of apoptosis may play an important role in the pathogenesis of gastric carcinoma.