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2012•Journal of Shangqiu Normal UniversityRequires access

Effects of EGCG on the proliferation and apoptosis and the expression of stat3 in BEL-7402 cells

Xuejun Xu

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Abstract

To study the effects of EGCG on the proliferation and apoptosis and the expression of Singnal transducer and activator of transcription-3(Stat3) in human hepatocellular carcinoma cell line BEL-7402.The effect of different concentrations of GECG on the proliferation was detected by MTT assay.The Flow cytometric analysis was performed to detect the cell apoptosis.ELISA assay was applied to test the expression of Stat3 and phosphorylation Stat3.EGCG could inhibit proliferation and induce apoptosis in a dose dependent manner in BEL-7402 cells.Moreover,EGCG down-regulated the expression of phosphorylation Stat3.EGCG inhibits growth inhibition and induces apoptosis in human heptocellular carcinoma cell line BEL-7402 possibly by down-regulating p-Stat3 expression.

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What this paper is about

To study the effects of EGCG on the proliferation and apoptosis and the expression of Singnal transducer and activator of transcription-3(Stat3) in human hepatocellular carcinoma cell line BEL-7402.The effect of different concentrations of GECG on the proliferation was detected by MTT assay.The Flow cytometric analysis was performed to detect the cell apoptosis.ELISA assay was applied to test the expression of Stat3 and phosphorylation Stat3.EGCG could inhibit proliferation and induce apoptosis in a dose dependent manner in BEL-7402 cells.Moreover,EGCG down-regulated the expression of phosphorylation Stat3.EGCG inhibits growth inhibition and induces apoptosis in human heptocellular carcinoma cell line BEL-7402 possibly by down-regulating p-Stat3 expression.

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Available abstract

To study the effects of EGCG on the proliferation and apoptosis and the expression of Singnal transducer and activator of transcription-3(Stat3) in human hepatocellular carcinoma cell line BEL-7402.The effect of different concentrations of GECG on the proliferation was detected by MTT assay.The Flow cytometric analysis was performed to detect the cell apoptosis.ELISA assay was applied to test the expression of Stat3 and phosphorylation Stat3.EGCG could inhibit proliferation and induce apoptosis in a dose dependent manner in BEL-7402 cells.Moreover,EGCG down-regulated the expression of phosphorylation Stat3.EGCG inhibits growth inhibition and induces apoptosis in human heptocellular carcinoma cell line BEL-7402 possibly by down-regulating p-Stat3 expression.

Key concepts: Apoptosis, STAT3, Cell growth, STAT protein, Cell culture, Phosphorylation, MTT assay, Flow cytometry

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Effects of EGCG on the proliferation and apoptosis and the expression of stat3 in BEL-7402 cells — Research Paper | ScholarLens