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2010•Journal of Modern StomatologyRequires access

The correlation between expression of COX-2 and lymphangiogenesis in oral squamous cell carcinoma

Lan Yang

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Abstract

Objective To investigate the correlation between expression of COX-2 and lymphangiogenesis in oral squamous cell carcinoma.Methods The expression of COX-2 and D2-40 in oral squamous cell carcinoma was evaluated by using immunohistochemistry,and the number of D2-40 positive lymphatic vessels were regarded as lymphatic vessel density(LVD).Results The expression of COX-2 in oral squamous cell carcinoma was higher than that in normal tissue,and the expression of COX-2 and LVD in oral squamous cell carcinoma with lymph node metastasis was significantly higher than that without lymph node metastasis respectively,the difference was statistically significant(P0.05).COX-2 expression was correlated with LVD in oral squamous cell carcinoma(r=0.552,P0.05).Conclusion COX-2 is a significant factor for lymphangiogenesis,which may be involved in the lymph node metastasis in oral squamous cell carcinoma.

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What this paper is about

Objective To investigate the correlation between expression of COX-2 and lymphangiogenesis in oral squamous cell carcinoma.Methods The expression of COX-2 and D2-40 in oral squamous cell carcinoma was evaluated by using immunohistochemistry,and the number of D2-40 positive lymphatic vessels were regarded as lymphatic vessel density(LVD).Results The expression of COX-2 in oral squamous cell carcinoma was higher than that in normal tissue,and the expression of COX-2 and LVD in oral squamous cell carcinoma with lymph node metastasis was significantly higher than that without lymph node metastasis respectively,the difference was statistically significant(P0.05).COX-2 expression was correlated with LVD in oral squamous cell carcinoma(r=0.552,P0.05).Conclusion COX-2 is a significant factor for lymphangiogenesis,which may be involved in the lymph node metastasis in oral squamous cell carcinoma.

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Available abstract

Objective To investigate the correlation between expression of COX-2 and lymphangiogenesis in oral squamous cell carcinoma.Methods The expression of COX-2 and D2-40 in oral squamous cell carcinoma was evaluated by using immunohistochemistry,and the number of D2-40 positive lymphatic vessels were regarded as lymphatic vessel density(LVD).Results The expression of COX-2 in oral squamous cell carcinoma was higher than that in normal tissue,and the expression of COX-2 and LVD in oral squamous cell carcinoma with lymph node metastasis was significantly higher than that without lymph node metastasis respectively,the difference was statistically significant(P0.05).COX-2 expression was correlated with LVD in oral squamous cell carcinoma(r=0.552,P0.05).Conclusion COX-2 is a significant factor for lymphangiogenesis,which may be involved in the lymph node metastasis in oral squamous cell carcinoma.

Key concepts: Lymphangiogenesis, Medicine, Immunohistochemistry, Basal cell, Lymphatic system, Lymphatic vessel, Lymph node metastasis, Pathology

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