Effect of ischemic postconditioning on the renal ischemia-referfusionreperfusion injury in rats

Objective:To establish a model of renal ischemia-reperfusion in rats.To investigate the effect of ischemic postconditioning on the renal ischemia-reperfusion(I/R) injury and its mechanism.Method:The model of rat's RIRI was established,30 wistar rats were randomly divided into 3 groups:false operating group(S),ischemia reperfusion group(I/R) and ischemic postconditioning(IPo).Blood urea nitrogen(BUN),creatinine(Cr),superoxide dismutase(SOD) werewas ditecteddetected in each groups.and renal histopathology lesions were examined.Result:In I/R group,BUN and SCr serum levels increased significantly after ischemia reperfusion compared with false operating group(P0.05),while BUN and SCr serum levels of IPo group decreased significantly after ischemic postconditioning compared with I/R group,there was statistic significance(P0.05).in I/R group,SOD serum levels decreased significantly after ischemia reperfusion compared with false operating group(P0.05),while SOD serum levels of IPo group increased significantly after ischemic postconditioning compared with I/R group,there was statistic significance(P0.05).in S group,gomeruli and tubules have no obvious pathological changes,in I/R group,there are significant distinction of the pathological scale which compared with S group,in IPo group,the histologic damage induced by I/R were significantly ameliorated,there were statistic significance(P0.05).Conclusion:Ischemic postconditioning play an important protective role in the renal ischemia-reperfusion injury,the mechanism is that which enhance kidney antioxidant capacity and reduce infiltration of inflammatory cells.