Clinical Significance of Squamous Cell Carcinoma Antigen in Patients with Cervical Intraepithelial Neoplasia and Early-stage Squanous Cell Carcinoma

[Purpose] To investigate the clinical value of squamous cell carcinoma antigen (SCCAg) level in the diagnosis and therapeutic efficacy monitoring of cervical intraepithelial neoplasia (CIN) and early-stage squamous cell carcinoma (SCC). [Methods] Serum SCC-Ag from 197 cases with early-stage SCC, 107 cases with cervical intraepithelial neoplasia (CIN) and 78 healthy controls was detected by microparticle En-zyme-immunoassay(MEIA). [Results] The level and the positive rate of SCC-Ag in early-stage SCC group were significantly higher than those in CIN and health controls (P=0.000), while the level and the positive rate of SCC-Ag in CIN and healthy controls was not significant (P0.05). The level of SCC-Ag in early-stage SCC increased with neoplasm staging from Ⅰ to ⅡA (P=0.000). The post-operation SCC-Ag level was significantly lower than that of pre-operation (P=0.000). [Conclusions] SCC-Ag level cannot be the diagnostic and screening criteria of CIN, but is helpful for the diagnosis and screening for early-stage SCC. SCC-Ag level is clinically valuable for evaluating the therapeutic efficacy of early-stage SCC postoperation.