2005•Journal of Shandong UnivenityRequires access

Experimental study on the changes of expressions of RARα and RARβ during neural tube defects induced by retinoic acid

Yingmao Gao

Abstract

Objective: To investigate the effect of excess retinoic acid (RA) on the expressions of RARα and RARβ in neural tube of golden hamsters. Methods: Through immunohistochemistry and image analysis methods, the difference of expressions of RARα and RARβ between normal and defected neural tube induced by excess RA was analyzed in golden hamsters. Results: Excess RA made the expressions of RARα and RARβ decline firstly, then increase significantly in neural tube of golden hamster. Conclusion: The expressions of RARα and RARβ induced by excess RA are related to the neural tube defects in golden hamster .

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Key concepts: Retinoic acid, Golden hamster, Neural tube, Hamster, Tube (container), Mesocricetus, Immunohistochemistry, Chemistry