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Effects of excessive retinoic acid on expression of RARα and RARβgenes in neural tube of golden hamster embryos

Lu Zhi

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Abstract

Objective: To investigate the effect of excessive retinoic acid (RA) on the expression of RARα and RARβ in the neural tube of golden hamster embryos. Methods: The changes of the RARα mRNA and RARβ mRNA induced by excessive RA in normally developed neural tube and neural tube defects of golden hamsters were analyzed with RT-PCR. Results: Excessive RA down-regulated the expressions of RARα mRNA and RARβ mRNA in the neural tube of golden hamster initially, and then up-regulated them significantly. Conclusion:The changes of RARα mRNA and RARβ mRNA expression induced by excessive RA are correlated with the neural tube defects of golden hamster induced by RA.

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What this paper is about

Objective: To investigate the effect of excessive retinoic acid (RA) on the expression of RARα and RARβ in the neural tube of golden hamster embryos. Methods: The changes of the RARα mRNA and RARβ mRNA induced by excessive RA in normally developed neural tube and neural tube defects of golden hamsters were analyzed with RT-PCR. Results: Excessive RA down-regulated the expressions of RARα mRNA and RARβ mRNA in the neural tube of golden hamster initially, and then up-regulated them significantly. Conclusion:The changes of RARα mRNA and RARβ mRNA expression induced by excessive RA are correlated with the neural tube defects of golden hamster induced by RA.

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Available abstract

Objective: To investigate the effect of excessive retinoic acid (RA) on the expression of RARα and RARβ in the neural tube of golden hamster embryos. Methods: The changes of the RARα mRNA and RARβ mRNA induced by excessive RA in normally developed neural tube and neural tube defects of golden hamsters were analyzed with RT-PCR. Results: Excessive RA down-regulated the expressions of RARα mRNA and RARβ mRNA in the neural tube of golden hamster initially, and then up-regulated them significantly. Conclusion:The changes of RARα mRNA and RARβ mRNA expression induced by excessive RA are correlated with the neural tube defects of golden hamster induced by RA.

Key concepts: Golden hamster, Neural tube, Retinoic acid, Hamster, Embryo, Mesocricetus, Messenger RNA, Biology

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Effects of excessive retinoic acid on expression of RARα and RARβgenes in neural tube of golden hamster embryos — Research Paper | ScholarLens