The Value Comparison of Serum and Urine MCP-1 Detection in Diagnosis of Children with Henoch-Schonlein Purpura Nephritis

Objective To compare the clinical value of serum and urine monocyte chemoattractant protein-1( MCP-1) detection in diagnosis of children with Henoch-Schonlein purpura nephritis( HSPN). Methods A total of 78 cases of children with HSPN according to UAER were divided into normal albuminuria group( group A,27 cases),microalbuminuria group( group B,25 cases),macroalbuminuria group( group C, 26 cases) according to urinary albumin excretion rate( UAER) and remission phase group( n = 36 cases), acute phase group( n = 42 cases). The expression level of MCP-1 in serum,urine,and the correlation of MCP-1 level and UAER were compared. Results With the increase of UAER,the expression level of MCP1 in all groups increased( P 0. 05),and the serum MCP-1 levels in every group showed no significant difference( P 0. 05). The urine MCP-1 levels in acute phase were higher than that of remission phase( P 0. 05),but serum MCP-1 levels showed no statistically significant difference between the remissions phase and acute phase( P 0. 05). The expression level of urinary MCP-1 in children with HSPN had a positive relationship with UAER( r = 0. 782,P 0. 05),but the expression level of serum MCP-1 in children with HSPN had no significant correlation with UAER( r = 0. 327,P 0. 05). Conclusion The urinary expression level of MCP-1 is closely correlated with renal tissue lesion degree and urinary protein in children with HSPN, which is of great significance for judging the disease prognosis of HSPN and guiding the clinical treatment.