The Role of Amifostine to Protect Hepatic Function in Chemotherapy Hepatic Artery Embolization

Objective To evaluate the role of amifostine in hepatic function protection after chemotherapy hepatic artery embolization(TACE).Methods Four hundred and eighty five cases of hepatic malignant tumors treated by TACE were selected retrospectively,which were divided into the treatment group(254 cases) and the control group(231 cases) according to the usage of amifostine.Total bilirubin(TB),ALT,AST and albumin were detected before TACE,4 days and 40 days after TACE respectively.Results Between before TACE and 4 days after TACE,the deviation values(DVs) of TB and AST in the treatment group were lower than that in the control group while A was on the contrary,which was significant(P 0.01) ;between before TACE and 40 days after TACE,DVs in both groups were not significant.In hepatic function of Child A,DV of TB between before TACE and 4 days after TACE in the treatment group was lower than that in the control group(P 0.01),while A was on the contrary(P 0.01) ;in Child B,DVs of all in treatment group were different significantly from those in the control group(P 0.01).Conclusion In TACE ammonia phosphoric christine has some protective effect on hepatic function,and the protective effect is more obvious in poor hepatic function;but for now the protective effect is limited,and the superiority of long protective effect on hepatic function is uncertain.