Plasma brain natriuretic peptide levels in the diagnosis of heart failure

【Objective】To investigate the relationship B-type natriuretic peptide (BNP) levels with the severity heart failure (HF) , and the left ventricular systolic function in patients with heart failure【.Methods】BNP levels 117 patients with HF were measured by immunofluorimetry. Colored doppler echocardiography was performed to measure the left ventricular systolic function.【Results】BNP levels increased with the deterioration the heart failure according to the NYHA classification. Cardiac function grade Ⅱ, BNP level 440.87 ± 437.34 (pg / ml), cardiac function grade Ⅲ, BNP level 833.98 ± 702.34 (pg / ml), cardiac function grade Ⅳ, BNP levels 1348.07 ± 933.46 (pg/ml). BNP 400 pg/ml patients, EF value only 33.0%, while BNP 400 pg/ml patients, EF value of 45% accounted for 66.7%(P =0.001); the BNP400 pg/ml in patients with Chinese, E/A1 accounted for 62.1%, while BNP 400 pg / ml in patients, E / A 1 accounted for 39.2%, (P =0.014)、BNP level was negatively correlated with left ventricular ejection fraction, and was related to the E/A ratio significantly. Unstable angina pectoris and the renal dysfunction were both influencing factors to plasma BNP levels 【.Conclusion】BNP level increased with the degree the heart failure severity, and it may be important to use BNP to predict left ventricular function.