Prognosis evaluation of B type natriuretic peptide in patients with congestive heart failure

Objective To investigate the prognosis evaluation in patients with congestive heart failure (CHF) by B type natriuretic peptide (BNP) assay.Methods 343 patients were admitted to hospital for CHF.BNP levels,left ventricular ejection fraction (LVEF),left ventricular end diastolic diameters(LVDD),cardiacthoracic ratio (CRT) were performed respectively in admission and before discharge.The rates of fatality and re-hospitalization were as end points during 3-month follow-up.Results 1.BNP levels were significantly different in different heart function classes according to NYHA (P0.001).The levels of BNP in patients with heart function class Ⅰ,Ⅱ,Ⅲ and Ⅳ were (157±15) pg/ml, (341±22) pg/ml,(597±33) pg/ml and (1245±38) pg/ml,respectively. 2.There was a significant negative correlation between BNP levels and LVEF (r=-0.8,P0.05).3.BNP level of 27 patients including 5 death and 22 re-hospitalization was (1683±124)pg/ml,however,BNP level of 316 patients in non-episode group was (468±348) pg/ml(P0.001).4.Sensitivity and specialty were 96.3% and 92.7% when BNP1500 pg/ml was as cut-off point before discharge. 5.Results of multiple factors step-wise regression analysis about gender,year,LVEF,LVDD,BNP and etiology etc showed that there was a most significant correlation between BNP and prognosis.Conclusion BNP level was more exact than LVEF in evaluating prognosis of CHF.Dynamic changes of BNP levels were effective marker in evaluating prognosis of CHF.