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HM-3 Inhibiting Angiogenesis in Vitro

Hanmei Xu

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Abstract

To investigate the inhibitory effect of HM-3 on angiogenesis in vitro.HM-3 antiangiogenesis effect was evaluated by using chick chorioallantonic membrane,rats aortic rings and Matrigel assay.Chick chorioallantoic membrane and rats aortic rings tests demonstrated that HM-3 effectively inhibited angiogenesis in vitro,the peptide HM-3 at the dose of 0.05 μg revealed the best inhibitory effect on chick chorioallantoic membrane.The most obvious effect on angiogenesis inhibition was observed at dose of 8 μg/mL on rats aortic rings.The most obvious blocking effect on the differentiation of HUVECs into tube-like structures was observed in vitro when the concentration of HM-3 was 7-8 μg/mL.Therefore HM-3 distinguishedly inhibited angiagenesis formed in vitro.

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What this paper is about

To investigate the inhibitory effect of HM-3 on angiogenesis in vitro.HM-3 antiangiogenesis effect was evaluated by using chick chorioallantonic membrane,rats aortic rings and Matrigel assay.Chick chorioallantoic membrane and rats aortic rings tests demonstrated that HM-3 effectively inhibited angiogenesis in vitro,the peptide HM-3 at the dose of 0.05 μg revealed the best inhibitory effect on chick chorioallantoic membrane.The most obvious effect on angiogenesis inhibition was observed at dose of 8 μg/mL on rats aortic rings.The most obvious blocking effect on the differentiation of HUVECs into tube-like structures was observed in vitro when the concentration of HM-3 was 7-8 μg/mL.Therefore HM-3 distinguishedly inhibited angiagenesis formed in vitro.

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Available abstract

To investigate the inhibitory effect of HM-3 on angiogenesis in vitro.HM-3 antiangiogenesis effect was evaluated by using chick chorioallantonic membrane,rats aortic rings and Matrigel assay.Chick chorioallantoic membrane and rats aortic rings tests demonstrated that HM-3 effectively inhibited angiogenesis in vitro,the peptide HM-3 at the dose of 0.05 μg revealed the best inhibitory effect on chick chorioallantoic membrane.The most obvious effect on angiogenesis inhibition was observed at dose of 8 μg/mL on rats aortic rings.The most obvious blocking effect on the differentiation of HUVECs into tube-like structures was observed in vitro when the concentration of HM-3 was 7-8 μg/mL.Therefore HM-3 distinguishedly inhibited angiagenesis formed in vitro.

Key concepts: Chorioallantoic membrane, Angiogenesis, In vitro, Matrigel, Chemistry, Inhibitory postsynaptic potential, Cell biology, Biology

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