Comparison of Total Intravenous Anesthesia of Remifentanil-Propofol with Intravenous Combined Desflurane Inhalation Anesthesia in Laparoscopic Cholecystectomy

Objective To compare the effects of total intravenous anesthesia of remifentanil-propofol with intravenous combined desflurane inhalation anesthesia in laparoscopic cholecystectomy(LC).Methods Forty patients underwent selective LC were randomized into experiment group(Group E) and control group(Group C),with 20 for each.Anesthesia were maintained with remifentanil 0.5μg/(kg·min) and propofol 6 mg/(kg·h) continual intravenous infusion in Group E and 10% desflurane inhalation in Group C.SBP,DBP,HR and SPO_2 were monitored at different time points: before anesthesia(T_0),before pneumoperitoneum(T_1),at 10 minutes after pneumoperitoneum(T_2),at the end of pneumoperitoneum(T_3),and at the end of operation(T_4).The endotracheal extubation time,OAAS score,conscious recovery,pain and unwell during operation,complications as nausea and vomiting after operation were recorded.Results(1) HR of T_2,T_3,T_4,SBP and DBP of T_2 were higher remarkably than those of T_0 in Group C(P0.05),whereas no obvious variations in Group E.Compared with Group E,HR and SBP of T_2,T_3,T_4 and DBP of T_2,T_3 were significantly higher in group C(P0.05).(2)There was no significant difference in the extubation time and conscious recovery between two groups.OAAS scores after extubation were higher and the occurrence of postoperative nausea and vomiting was lower in Group E than those of Group C(P0.05).Conclusion Compared with intravenous anesthesia plus desflurane inhalation,total intravenous anesthesia of remifentanil-propofol could be more suitable in LC with stable hemodynamics,fast conscious recovery and less complications.