The correlation of serum MMP-9,hs-CRP and carotid artery IMT in patients with acute cerebral infarction

Objective To observe the serum MMP-9 and hs-CRP′s level change in patients with acute cerebral infarction(ACI),and discuss their correlation with carotid artery IMT.Methods By ELISA method and latex enhancement immunity turbidimetric method respectively,the serum levels of MMP-9 and hs-CRP in 185 patients with ACI and 45 healthy people were tested.Results(1)Serum levels of MMP-9 and hs-CRP in ACI patients were significantly higher than those in control group(P0.01),and serum levels of MMP-9 and hs-CRP in carotid plaques formation group were higher than those of carotid intimal hyperplasia group and carotid intima normal group(P0.01),and those of carotid intimal hyperplasia group were higher than those of carotid intima normal group(P0.01),and those of carotid intima normal group were higher than those of control group(P0.01).The serum levels of MMP-9 and hs-CRP increased with the rise of IMT value.(2) The serum levels of MMP-9 and hs-CRP in patients with ACI had a positive correlation to IMT values(r=0.357,0.409,P0.01),and serum level of MMP-9 had a positive correlation to serum level of hs-CRP(r=0.415,P0.01).Conclusion The serum levels of MMP-9 and hs-CRP in patients with ACI were significantly higher than those in the control group,which have a positive correlation to IMT values.Combined detection on serum MMP-9 and hs-CRP′s level can be important parameters to judge illness severity,clinical curative effect and prognosis evaluation in patients with ACI.