The Susceptibility Weighted Imaging Investigation in Patients with Parkinson's Disease

Objective: To investigate the Susceptibility Weighted Imaging(SWI) appearance of patients with Parkinson's disease(PD).Methods: 34 patients with PD(case group) and 30 health person(control group) were chosen.All cases were under conventional fast-spine echo T1WI,T2WI and 3-dimentional SWI covering basal ganglia and midbrain with GE 1.5T signa MR system.Phase shift of caput nuclei caudate,globus pallidus,putamen,substantia nigra and red nucleus were detected twice in corrected phase images.The last phase shift is the average of the twice.Results: The phase shift of case group was obviously lower than that in control group in substantia nigra and putamen,and the difference have statistical significance(P 0.05).It illustrate that iron deposition increased in the case group.The phase shift of putamen had negative correlation with the course of disease in the case group.The caput nuclei caudati,putamen and substantia nigra's phase shift are lower in left than that in right in the control group.Conclusion: SWI is an effective examination in mani-festing PD's iron deposition.