Safety and efficacy of domestic and imported cefepime in treatment of lower respiratory tract bacterial infection in 120 patients

AIM:To evaluate the clinical efficacy and safety of domestic cefepime in the treatment of low- er respiratory tract bacterial infections.METHODS:A multi-center,randomized,double blind,parallel-group, comparative study of cefepime was eondueted among 121 patients with respiratory infections.They were random- ized into trial group(61 patients,treated with domestic cefepime,2 g,iv,gtt,bid,for 7-14 days)and control group (60 patients,treated with imported cefepime,2 g,iv,gtt,bid,for 7-14 days).RESULTS:The recovery and ef- fective rates were 66% and 98% in trial group,80% and 100% in control group;the positive rates of bacterial culture were 79% and 83%;the bacterial clearance rates were 98% and 100%;the incidence rates of adverse reactions were 10% and 3%,respectively.There were no significant differences between two groups(P＞0.05). CONCLUSION:Domestic cefepime has the same safety and efficacy as imported one in the treatment of lower respiretory tract bacterial infection.