Randomized contorl clinical study on safety and efficacy of domestic cefepime in the treatment of lower-respiratory tract bacterial infections

Objective:To evaluate the safety and efficacy of domestic cefepime in the treatment of lower-respiratory tract bacterial infections.Methods:A double-blind,randomized control clinical trial of intravenous cefepime on patients with lower-respiratory tract bacterial infections were conducted.The regimen of the two groups were 2g,twice daily for 7 to14ds.Both drugs were given intravenously.Results:In this trial,30 patients were enrolled in trial group and other 30 patients were enrolled in control group.The overall efficacy rates and cure rate in trial and control group were 93.33%?63.33% and 96.67%?70% respectively.The bacterial clearance rates were 96% and 100% respectively,and the adverse drug reaction rates were 3.3% and 0%. There was no statistical significant differences in the above results between the two groups.The activity of cefepime against gram-positive organisms was generally higher than that of the other 4 antibacterial agents.Conclusion:The results suggested that demostic cefepime with powerful antibacterial activity and wide spectrum has the same safety and efficacy as imported one in treating lower-respiratory tract bacterial infections.