Clinical Study of “Huaiqihuang Granule”for Preventing Recurrent Respiratory Infections in Children with Bronchial Asthma

Objective: To observe the clinical effect of Huaiqihuang Granulefor preventing respiratory infections in children with bronchial asthma. Methods: Seventy-two children with bronchial asthma were randomly divided into treatment group and control group with 36 cases in each group. All the children were treated with salmeterol and fluticasone propionate inhaled and montelukast sodium orally,and the treatment group was treated withHuaiqihuang Granulein addition,with a course of 3 months. The infection occurrence,immune function and lung function were observed and compared,and all the children were evaluated by Chinese-Childhood Asthma Control Test( Ch-CACT). Results: Throughout the study period,the ratio of infection was 21. 9% in the treatment group,and the ratio of infection in the control group was 34. 3%,with statistical difference between two groups( P 0. 05). After treatment and three months after treatment,the levels of IgA,IgG,IgM, CD3+,CD4+and CD4+/ CD8+in treatment group were significantly increased( P 0. 05),and the level of IgE was significantly decreased( P 0. 05); 3 months after treatment,the levels of IgA,IgG,IgM,CD3+,CD4+,CD8+and CD4+/ CD8+in control group were also obviously increased( P 0. 05),and the level of IgE was significantly decreased(P 0. 05); and after treatment and three months after treatment,the levels of IgA,IgG,IgM,CD3+,CD4+and CD4+/ CD8+in treatment group were higher than those in control group( P 0. 05). After treatment and three months after treatment,the levels of FEV1and PEF and the scores of Ch-CACT in both groups were significantly higher than before treatment(P 0. 05). Conclusion: Huaiqihuang Granulecan improve the immune function,reduce the occurrences of infection and asthma,and prevent the respiratory infections in children with bronchial asthma.