Distribution and drug resistance of common pathogens in hospital

OBJECTIVE To investigate the distribution and drug resistance of the common pathogens isolated from the hospital so as to guide the reasonable use of antibiotics.METHODS The clinical samples such as blood,urine,stool,and all kinds of secretions were collected from the hospitalized patients from Jan to Dec 2011,then the bacterial identification and the drug susceptibility testing were performed according to the National Clinical Laboratory Procedures(third edition).RESULTS A total of 264 pathogenic bacteria were detected,among which there were 69 strains of gram-positive bacteria (26.1%),153 strains of gram-negative bacteria (58.0%) and 42 strains of fungi (15.9%).Among the gram-negative bacteria,the Pseudomonas aeruginosa and Escherichia coli were the predominant species,accounting for 19.3%and 12.15,respectively.The drug resistance rates of P.aeruginosato clindamycin,ceftriaxone,and ampicillin were 100.0%,92.2%,and 92.2%,respectively,and the drug resistance rates of E.coli to ciprofloxacin,clindamycin,piperacillin,and ampicillin were 51.6%,93.8%,79.7%,and 82.8%,respectively.Among the gram-negative bacteria,the A.baumannii strains were naturally resistant and multidrug-resistant to ampicillin,the first-generation,and second-generation of cephalosporins;the Staphylococcus aureus was the predominant gram-positive bacteria and were highly resistant to clindamycin,azithromycin,and piperacillin.CONCLUSIONIt is necessary to strengthen the monitoring of drug resistance of P.aeruginosa,E.coli,and A.baumannii,and the reasonable use of antibiotics can further curb the spread of bacterial resistance.