The expression and clinical significance of E-Cadherin in esophageal carcinoma

Objective To discuss E-cadherin expression in esophageal cancer and to study its impacts on the prognosis of esophageal cancer.MethodsImmuno-histochemistry method was used to detect esophageal squamous cell carcinoma and adjacent normal esophageal tissue of E-cadherin expression.ResultsThe expression of E-cadherin in esophageal cancer tissue was lower than that in normal next to esophageal cancer organizations,the expression of E-cadherin in esophageal cancer patients was not related to gender,nationality,tumor location,size,degree of differentiation and cancer clinical pathology stages.ConclusionCompared to the adjacent normal esophageal organizations,esophageal squamous cell carcinoma of the E-cadherin expression is low or no expression,suggests that the tumor in the development process along with the role of cell adhesion loss.