Clinical efficacy evaluation of combining Tripterygium mixture in the treatment of rheumatoid arthritis with damp-heat-blockage syndrome

Objective: To explore the clinical efficacy evaluation of the treatment of rheumatoid arthritis with damp-heat-blockage syndrome combining tripterygium mixture. Methods: According to disease activity, divided 72 cases of eligible subjects randomly into the treatment group (36 cases) and the control group (36 cases). Treatment groups were given methotrexate combined use of leflunomide (Western medicine) and tripterygium mixture combined use of xuanbi ermiao San (traditional Chinese medicine). Control groups were given methotrexate combined use of leflunomide (Western medicine) and xuanbi ermiao powder (traditional Chinese medicine). Observe them for 12 weeks. Detection index: pre-treatment, 4 weeks, 8 weeks and 12 weeks after treatment TJC (tender joint count), SJC (swollen joint count), ESR (erythrocyte sedimentation rate), CRP (c-reactive protein), GH and DAS 28 (disease activity assessment 28) were recorded. Results: ① There was no significant differences in six indicators before treatment (P0.05), they were comparable. ② There was significant differences in six indicators after 4 weeks, 8 weeks, 12 weeks from those before treatment respectively(P0.05). There was no significant differences in the ESR, CRP of the control group after four-week treatment from those before treatment(P0.05), While after 8-week and 12-week treatment P0.05, there were significant differences, which indicated that the treatment group got rapid onset ofcontrol group. There was significant differences in TJC, SJC and DAS28 of the control group after 4 weeks, 8 weeks and 12weeks from those before treatment( P0.05), ③ There were differences in inflammatory index ESR, CRP, after 4 weeks, 8 weeks and 12 weeks respectively between the two groups(P0.05). There were no differences in TJC and SJC after 4 weeks, 8 weeks and 12 weeks respectively between the two groups (P0.05). There were differences in DAS28 and GH after 4 weeks and 8 weeks respectively between the two groups(P0.05), but after 12 weeks there were differences between the two groups (P0.05). Conclusion: Treatment of damp-heat-blockage rheumatoid arthritis combined use of tripterygium mixture made a fast onset of improving inflammatory index, better than that of the control group, GH of the patients was higher than that of the control group after 12 weeks, and so was the DAS28.