Relationship between cardiac function and angiogenesis after rat myocardial infarction

Objective To explore the relationship between changes of heart function and angiogenesis after myocardial infarction,and provide morphological reference for clinical treatment of myocardial infarction. Methods Acute myocardiac infarction( AMI) model was established with Sprague-Dawley rats by ligation of the left anterior descending coronary artery. Cardiac function at different weeks after AMI was evaluated by echocardiography. The change of Ⅷ factor and vascular endothelial growth factor( VEGF) expression at the infarction edge in rats hearts at each week after AMI was detected by immunohistochemistry and Western blotting. Results The cardiac function of 1W after myocardial infarction was worst,cardiac function was improved during 2 weeks and 3weeks,but reduced at the 4th week; Ⅷ factor and VEGF in post-myocardial infarction 1 week,2 weeks were highly expressed. Expression of both factors began to decrease at the 3rd week. At the 4th week,expression levels were close to normal. Conclusion The change of cardiac function after myocardial infarction is inconsistent with that of angiogenesis,early increased vascular density can not obviously improve cardiac function.