Analysis of Glucose Challenge Test and levels of insulin releasing in pregnant women

Objective To observe levels of glucose and insulin in pregnant women at 24-28weeks of gestation,to understand degree of insulin resistance,to investigate the value of 50g Glucose Challenge Test in diagnosis of gestational diabetels mellitus(GDM).Methods 550 pregnant women with 50g GCT in our hospital,these were divided into groups,whose 50g GCT values were ≥7.8 mmol/L,≤7.8 mmol/L.Insulin was measured by radioimmunoassay.Results The fasting glucose levels of normal GCT(4.36±0.33 mmol/L) were significantly lower than healthy non-pregnant women.The fasting glucose levels of abnormal GCT(4.53±0.35 mmol/L) weren's significantly different with mormal GCT and healthy non-pregnant women.There were 112 cases with abnormal GCT,13 cases of GDM(2.4%),30 cases of GIGT(5.5%).The fasting insulin and the insulin at the first hour postprandially of pregnant women with abnormal GCT were significantly higher than that with nomarl GCT.Conclusions The pregnant women display accelerating starvation with clinical symptoms of relatively lower fasting glucose concentration.The 50g GCT value is important in the diagnosis of GDM.The pregnant women with abnormal GCT,but with normal OGTT,are possible to develop GDM with pregnant progress.