Association between Variation of Maternal Glucose Concentration and Pregnant outcome in Pregnant Women with Normal Glucose Tolerance Test

Objective:To study the relationship between pregnant outcome and blood glucose concentration in pregnant women with normal Oral Glucose Tolerance Test(OGTT) and abnormal Glucose Challenge Test(GCT).Methods:Medical histories of 990 pregnant women in Shanghai Jiaotong University Sixth Affiliated Hospital between Jun.2003 and Dec.2005 were retrospectively abstracted.After comparing GCT,OGTT,fetal body weight,ad delivery mode,there were 359 cases of normal OGTT and abnormal GCT.Results:The prevalence of macrosomia and dystocia were higher in normal OGTT,abnormal GCT pregnant women(11.1%) than normal GCT women(5.8%);And the fasting blood glucose,2 hr glucose levels and glucose area under curve(AUC) of OGTT in macrosomia were higher than those with normal body weight.In women whose fasting glucose 4.62mmol/L,2 hr glucose 8.31mmol/L,and glucose AUC 22.77mmol/L in OGTT,the incidence of macrosomia and cesarean section increased.The glucose value associated with fetal body weight when 2 hr glucose over than 8.31mmol/L.Conclusions:This result notes that monitoring of 2 hr blood glucose concentration is more important than fasting blood glucose concentration.Attention should also be put on those pregnant women who have normal Oral Glucose Tolerance Test,abnormal Glucose Challenge Test.