Preparation and Property of Hydroxypropyl Chitosan Microspheres

Hydroxypropyl chitosan was synthesized from chitosan and propylene oxide.Using it as the shell material,insulin as the core was prepared microspheres single-pool preparation and the performance of microspheres was studied.Microspheres was prepored by single coacervation.The microspheres chemical structure was characterized by IR,XRD and DCS,morphology was observation using optical microscopy and scanning electron microscopic and the stability of microspheres was inspected.When stirring speed was 400 r/min,crosslinker dosage 0.15 mL,hydroxypropyl-chitosan concentration was 8 %,the shape of microspheres were better,encapsulation efficiency was 63 %,particle size was medium and distribution narrow was scope.The stability was appropriate under a variety of environmental.Microspheres of hydroxypropyl chitosan coated insulin performance studies was showed that the microspheres met the medical need.