Study on Protective Action of Propolis on Chemical-induced Liver Injury Caused by Ethanol

Objective To study the protective effect of propolis on chemical-induced liver injured by ethanol.Methods Fifty male Kunming mice were divided into 5 groups randomly:blank control group,model control group with hepatic injury,low-,middle-and high-dose propolis groups.Ethanol was given to mice by oral gavage once in order to make the acute liver injury model at the end of experiment.The content of MDA and GSH in hepatic tissue was detected by kit.The content of TG in hepatic tissue was detected by automatic biochemistry analyzer and the pathological change of fat in hepatic tissue was determined.Results The content of TG in high-dose propolis group was significantly lower than that in model control group,while the content of GSH in high-dose propolis group was significantly higher than that of model control group,and the difference was statistically significant (P0.05 or P0.01).The pathological change of fat in hepatic tissue in high-dose propolis group was significantly less than that of model control group,and there were statistically significant differences between the two groups(P0.01).Conclusions Propolis has the function of protecting the liver from chemical-induced injury caused by ethanol.