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2007•Medical Journal of Chinese People's HealthRequires access

Comparative study between venlafaxine and paroxetine in treatment of depression

Jingbo Song

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Abstract

Objective:To evaluate the efficacy and side effect of venlafaxine in the treatment of depression.Methods:63 out-patients and in-patients were divided into two groups,treated by venlafaxine and paroxetine respectively for 6 weeks.The efficacy was assessed by Hamilton depression rating scale(HAMD) and the safety was assessed by Rating Scale for Side Effects(SERS).Results: After 6 weeks treatment,the efficacy rate of the venlafaxine group and paroxetine group were 80.6% and 74.2%,respectively.The results have no remarkable differences in two groups(P0.05).but venlafaxine group's convalescing rate achieved 51.6% and the paroxetine group 25.8%,The results have remarkable differences in two groups﹝P0.05).And the paroxetine group took effect more quickly.Conclusions: Venlafaxine is a safe and effective antidepressant.It has faster efficacy.

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What this paper is about

Objective:To evaluate the efficacy and side effect of venlafaxine in the treatment of depression.Methods:63 out-patients and in-patients were divided into two groups,treated by venlafaxine and paroxetine respectively for 6 weeks.The efficacy was assessed by Hamilton depression rating scale(HAMD) and the safety was assessed by Rating Scale for Side Effects(SERS).Results: After 6 weeks treatment,the efficacy rate of the venlafaxine group and paroxetine group were 80.6% and 74.2%,respectively.The results have no remarkable differences in two groups(P0.05).but venlafaxine group's convalescing rate achieved 51.6% and the paroxetine group 25.8%,The results have remarkable differences in two groups﹝P0.05).And the paroxetine group took effect more quickly.Conclusions: Venlafaxine is a safe and effective antidepressant.It has faster efficacy.

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Available abstract

Objective:To evaluate the efficacy and side effect of venlafaxine in the treatment of depression.Methods:63 out-patients and in-patients were divided into two groups,treated by venlafaxine and paroxetine respectively for 6 weeks.The efficacy was assessed by Hamilton depression rating scale(HAMD) and the safety was assessed by Rating Scale for Side Effects(SERS).Results: After 6 weeks treatment,the efficacy rate of the venlafaxine group and paroxetine group were 80.6% and 74.2%,respectively.The results have no remarkable differences in two groups(P0.05).but venlafaxine group's convalescing rate achieved 51.6% and the paroxetine group 25.8%,The results have remarkable differences in two groups﹝P0.05).And the paroxetine group took effect more quickly.Conclusions: Venlafaxine is a safe and effective antidepressant.It has faster efficacy.

Key concepts: Paroxetine, Venlafaxine, Hamd, Rating scale, Depression (economics), Antidepressant, Internal medicine, Hamilton depression scale

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