Changes of high mobility group protein B1 and interleukin-18 levels in plasma of patients with coronary heart disease

Objective To research the clinical significance of changes of high mobility group B1(HMGBl) and interleukin-18 levels in plasma of patients with coronary heart disease(CHD),and provide reference for the diagnosis and treatment of CHD.Methods One hundred and two cases of CHD were diagnosed in our hospital,and the control group were 52 healthy people.5ml morning fasting venous blood was collected in EDTA-Na2 anticoagulant tube,and then centrifuged for 15 minutes with 3000 r/min,and last detected the levels of HMGBl and IL-18 by ELISA method.Results The levels of HMGBl and IL-18 in CHD group were significantly higher than control group(P0.01),and there was a positive correlation between HMGBl,IL-18 levels and the severity of coronary artery disease(P0.05).Conclusion The changes of HMGBl and IL-18 levels confirm that inflammatory reaction plays an important role in the occurrence and development of CHD.The plasma levels of HMGBl and IL-18 may be regarded as markers of CHD progression.