Relationship of postprandial blood pressure and pulse pressure with organ damages in metabolic syndrome

Objective To investigate the relationship of postprandial blood pressure(BP) and pulse pressure(PP) with organ damages in metabolic syndrome.Methods Two hundreds and thirty-three patients were divided into essential hypertension(EH,85 cases),type 2 diabetes mellitus(DM,75 cases),and metabolic syndrome(MS,73 cases).All patients were examined by 24h ambulatory blood pressure monitoring,carotid artery plaque rate(CAPR),intimal medial thickness(IMT),left ventricular mass index(LVMI),the ratio between early diastolic peak flow velocity and atrial peak flow velocity(E/A),creatinine clearace rate(CcR),24h microalbuminuria(MA).Results(1) In EH subjects,CAPR,IMT,LVMI,MA were increased in postprandial change in SBP or PP≥10mm Hg compared with SBP or PP10mm Hg(P0.01).E/A and CcR were decreased in the former than latter(P(0.01)).(2) In MS subjects,CAPR,IMT,LVMI,MA were increased in postprandial change in PP≥10mm Hg compared with PP10mm Hg(P0.01).E/A and CcR were decreased in the former than latter(P0.01).(3) In MS and DM groups,MA were increased in postprandial change in SBP≥10mm Hg and DBP≥5mm Hg compared with SBP10mm Hg and DBP5mm Hg(P(0.05),P0.01).(4) In three groups,IMT,LVMI,MA significantly were correlated with postprandial SBP and PP at1h.In MS and EH subjects,IMT,LVMI,MA significantly were correlated with 24h PP.Conclusion The postprandial BP and PP are the risk factors for the intimal medial thickness,left ventricular mass index,and 24h microalbuminuria of metabolic syndrome.