The clinical research of radiation-induced lung injury on the three radiotherapy methods for the postoperative stage II and III breast cancer

Objective To evaluate the effect of the three radiotherapy methods by comparing the occurrence of radiation-induced lung injury in receiving radiotherapy on the chest wall and supraclavicular area of the postoperative stageⅡand Ⅲ breast cancers..Methods:156 cases were divided into three groups according to different radiotherapy methods,conventional radiotherapy (groupA)which gives full electron-radiotherapy of 50 Gy/25f,conventional and intensity modulated radiotherapy(IMRT)(groupB) which gives 18 Gy/9f of IMRT after conventional electronradiotherapy of 32 Gy/16f,conventional and three-dimensional conformal radiotherapy(3DCRT)(groupC) which gives 18 Gy/9f of 3DCRT after conventional electron-radiotherapy of 32 Gy/16f.Results:There are statistical differences in the occurrence of radiation-induced lung injury and distant metastasis rates in three groups(P0.05).For the occurrence of radiation-induced lung injury,there are statistical differences only in group conventional radiotherapy and conventional and intensity modulated radiotherapy(IMRT)(P0.05).There are no statistical differences in the incidences of radiation-induced lung injury and distant metastasis rates in other groups(P0.05);Conclusion:conventional and intensity modulated radiotherapy(IMRT) can reduce the occurrence of radiation-induced lung injury,better control distant metastasis rate of the postoperative stageⅡand Ⅲ breast cancers.