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2010•Zhongguo shiyan fangjixue zazhiRequires access

Shange Lipid-lowering Dispersible Tablets of Puerarin in Rats in vivo Pharmacokinetic Study

Jing Wang

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Abstract

Objective: To comparative research puerarin of Shange lipid-lowering dispersible tablets and Gegen dispersible tablets in rats in vivo pharmacokinetics.Method: With vanillin as internal standard,HPLC was used to determine the contents of puerarin in rat plasma.Result: The main pharmacokinetic parameters of Shange lipid-lowering dispersible tablets: Tmax(3.000 ± 0.371) h,Cmax(3.159 ± 0.415) mg·L-1,AUC0→∞(19.593 ± 3.168) mg·L-1.h-1,MRT0→∞(11.370 ± 2.358) h;The main pharmacokinetic parameters of Gegen dispersible tablets: Tmax(4.000 ± 0.313) h,Cmax(2.784 ± 0.398) mg·L-1,AUC0→∞(17.605 ± 3.993) mg·L-1·h-1,MRT0→∞(8.678 ± 1.625) h.Conclusions:The extract of Hawthorn leaves and Pueraria combination can speed up the absorption of puerarin,the concentration increases and elimination of slow down.By the analysis of compartment model,it is two compartment model.

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What this paper is about

Objective: To comparative research puerarin of Shange lipid-lowering dispersible tablets and Gegen dispersible tablets in rats in vivo pharmacokinetics.Method: With vanillin as internal standard,HPLC was used to determine the contents of puerarin in rat plasma.Result: The main pharmacokinetic parameters of Shange lipid-lowering dispersible tablets: Tmax(3.000 ± 0.371) h,Cmax(3.159 ± 0.415) mg·L-1,AUC0→∞(19.593 ± 3.168) mg·L-1.h-1,MRT0→∞(11.370 ± 2.358) h;The main pharmacokinetic parameters of Gegen dispersible tablets: Tmax(4.000 ± 0.313) h,Cmax(2.784 ± 0.398) mg·L-1,AUC0→∞(17.605 ± 3.993) mg·L-1·h-1,MRT0→∞(8.678 ± 1.625) h.Conclusions:The extract of Hawthorn leaves and Pueraria combination can speed up the absorption of puerarin,the concentration increases and elimination of slow down.By the analysis of compartment model,it is two compartment model.

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Available abstract

Objective: To comparative research puerarin of Shange lipid-lowering dispersible tablets and Gegen dispersible tablets in rats in vivo pharmacokinetics.Method: With vanillin as internal standard,HPLC was used to determine the contents of puerarin in rat plasma.Result: The main pharmacokinetic parameters of Shange lipid-lowering dispersible tablets: Tmax(3.000 ± 0.371) h,Cmax(3.159 ± 0.415) mg·L-1,AUC0→∞(19.593 ± 3.168) mg·L-1.h-1,MRT0→∞(11.370 ± 2.358) h;The main pharmacokinetic parameters of Gegen dispersible tablets: Tmax(4.000 ± 0.313) h,Cmax(2.784 ± 0.398) mg·L-1,AUC0→∞(17.605 ± 3.993) mg·L-1·h-1,MRT0→∞(8.678 ± 1.625) h.Conclusions:The extract of Hawthorn leaves and Pueraria combination can speed up the absorption of puerarin,the concentration increases and elimination of slow down.By the analysis of compartment model,it is two compartment model.

Key concepts: Puerarin, Cmax, Pharmacokinetics, Pueraria, Chromatography, In vivo, Chemistry, Absorption (acoustics)

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