Study on pharmacokinetics of sulfamonomethoxine long-acting injection in pigs

The objective of the study was to investigate pharmacokinetic properties of sulfamonomethoxine long-acting injection in pigs. Twelve pigs were allotted to two groups at 6 pigs per group. The pigs in two groups were administered muscularly with sulfamonomethoxine long-acting injection A and sulfa- monomethoxine long-acting injection B respectively at the dose of 0.4 mL/kg body weight. Blood samples at 5 mL each time were collected from front cavity veins at different intervals after administration. The drug concentrations in plasma were analyzed by HPLC, and then the pharmacokinetic parameters were calculated by using MCPKP software. The results of the sulfamonomethoxine long-acting injection A were as follows: C_(max)=22.30 μg/mL±2.09 μg/mL, AUC=533.58 μg/(mL·h)±30.76 μg/(mL·h) and t_(1/2)_β=(20.20) h±5.31 h. The results of the sulfamonomethoxine long-acting injection B were as follows: C_(max)=15.96 μg/mL±2.36 μg/mL, AUC=199.91 μg/(mL·h)±11.31 μg/(mL·h) and t_(1/2)_β=9.81 h±1.03 h.