Clinical Study of Ulinastatin Combined with Low-dose Methylprednisolone on Patients with Acute Respiratory Distress Syndrome

Objective:To assess the clinical study of ulinastatin combined with low-dose methylprednisolone on patients with acute respiratory distress syndrome.Methods:Fifty-six patients with ALI/ARDS were randomly divided into control group and treatment group(n=28).Both groups were given low-dose methylprednisolone,and treatment group were additionally treated with ulinastatin.The differences between two groups were compared in respiratory rates,arterial blood gas,breathing mechanics ventilator,the TNF-α and IL-10 levels in BALF,lactic acid,Murray lung injury score,the duration of mechanical ventilation,ICU admission time,APACHEⅡscore before and after treatment.Results:After the treatment,two groups of patients with respiratory rates,arterial blood gas,breathing mechanics ventilator,the TNF-α and IL-10 levels in BALF,lactic acid and the duration of mechanical ventilation,ICU admission time and APACHEⅡscore are improved significantly(P0.05),but the improvement of all these indexes were more marked in A group(P0.05).Conclusion:Effects of ulinastatin combined with low-dose of methylprednisolone on acute respiratory distress syndrome has good therapeutic effects.