An analysis of six kinds of serum tumor markers detection in patients with lung cancer

Objective To investigate the prognostic value of detecting 6kinds serum tumor markers in lung cancer.Methods Serum tumor markers of carbohydrate antigen 125(CA-125)and carbohydrate antigen 19-9(CA19-9),carcinoma embryo antigen(CEA),cell keratin 19 pieces(Cyfra21-1),neuron specific enolase(NSE),enzyme-related squamous cell carcinoma antigen(SCC) were detected in 86patients with lung cancer(group A)and 50patients with benign lung disease(group C).Results Serum levels of CA19-9,CA-125,CEA,SCC,Cyfra21-1and NSE were higher in group A than those in group C(P0.05).Serum levels of CA-125and CA19-9were higher,but CEA and NSE were lower,in patients with small cell carcinoma than those in patients with non-small cell carcinoma(P0.05).Serum levels of CA-125and SCC were higher,but CA19-9and CEA were lower,in patients with squamous cell carcinoma than those in patients with adenocarcinoma(P0.05).Combined detection of 6kinds of tumor markers showed a sensitivity of 94.19% and specificity of 84.00% in the diagnosis of lung cancer.When a single tumor marker was detected, CA-125had the highest sensitivity and Cyfra21-1had the highest specificity.Conclusion Multiple serum tumor markers detections can improve the sensitivity in the diagnosis of lung cancer.